Imipramine antidepressant medicine

Imipramine belongs to the group of tricyclic antidepressants and is a dibenzazepine-derivative TCA. This medicine is indicated for the treatment of various mood conditions like depression and as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older.

Other indications are attention-deficit/hyperactivity disorder ADHD, bulimia nervosa, eating disorders, major depressive disorder, neuropathic pain, panic attacks, anxiety and agoraphobia.

Imipramine can be applied in patients with symptoms of panic disorders, acute depressive episodes in bipolar disorder and schizophrenia. It can be used for symptomatic treatment of postherpetic neuralgia.

Unlabeled indications of treatment are: chronic and neuropathic pain such as diabetic neuropathy, and post-traumatic stress disorder (PTSD).

In all indications either structural or unlabeled the medicine should be taken only with a prescription of a doctor.

The off-label indication of Imipramine in patients with no signs of depression often has a goal to produce sedation.

Patients with symptoms of depression benefit from the treatment as soon as increase of serotonergic neurotransmission occurs due to the actions of Imipramine.

Imipramine is a potent inhibitor of serotonin and norepinephrine reuptake. It also blocks histamine H1 receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for its sedative, hypotensive and anticholinergic effects. Urinary retention and sedation are due to the direct actions of Imipramine on serotonin reuptake and its anticholinergic effects.

When regularly used, Imipramine can be effective as a prophylaxis of migraine headaches.

The onset of action is observed usually as soon as 2-4 weeks after the medicine is started. The individual response to the treatment differs in patients.

Food can be used with this medicine. Still patients should avoid tea and coffee, and must not use alcohol. Imipramine is for oral administration.

Dose choice for adults and children is made with accordance to various factors.

Adult patients usually receive 1 tablet of Imipramine 25mg up to three times a day with the dose increase to 150-200mg. The increments of the dose should be steady to achieve the result and maintain it during the period of treatment.

Other dose adjustments are possible. Still the doses of 100 mg taken 3 times a day must be regulated and supervised by a caring doctor in clinical conditions.

Adult patients over the age of 60 usually respond to lower doses of this medicine. They are recommended to start with 10mg daily, gradually increasing to 30-50mg.

Children are prescribed Imipramine only for nocturnal enuresis. The medicine should be given right before bedtime. The medicine dose for children should not exceed 75 mg daily.

Contraindicating cases are: hypersensitivity to any of the excipients in the tablets of Imipramine, allergic reactions to any component, serious cardiac arrhythmias, recent myocardial infarction, liver or kidney disease.

Before starting treatment it is advisable to inform a doctor about all other medicines you use. Your doctor may adjust special tests before you begin the treatment.

Amoxicillin can cause hypersensitivity and allergies

Amoxicillin is a type of penicillin antibiotic used for infections in adults and children. Amoxil is a brand medicine containing amoxicillin and produced in the form of capsules and oral suspension.

The uses of Amoxil are very wide from common bacterial infections of the throat or ear infections to dental infections, urine infections and chest infections.

Additionally the medicine is used in combination with other drugs to treat people with Helicobacter pylori.

The usage of the medicine should be discussed with a doctor. The medicine is to be consumed only in cases related to infectious diseases caused by susceptible bacteria. If the cause of the disease is virus or fungi, the antibiotic Amoxil should not be used. The overuse or misuse of antibiotics leads to frequent events of drug-resistant bacteria development and/or to making the antibiotics of various types ineffective.

So, before the treatment a patient needs to visit a doctor and/or make certain tests to make sure that the medicine is suitable for him/her.

Amoxil can produce hypersensitive and allergic reactions in certain groups of patients. If you know about pre-existing allergy to any penicillin antibiotic, you should not use Amoxil. It may provoke allergic reaction of severe character. The same relates to people who are allergic to other types of antibiotics or have hypersensitivity to other medicines.

If after taking a pill of Amoxil you experience allergies reaction such as hives, rash, difficulty breathing, swelling and others, call your caring doctor right away. You may be suffering from very serious side effect of this medicine.

It is very likeable that your doctor recommends you to stop using the medicine and adjusts other treatment.

The reactions to the medicine can be individual, so not all reactions are so serious that you should discontinue using your drug. Please, be watchful for the serious side effects, but do not panic you have some itching which soon disappears.

If you buy this antibiotic online, check with your doctor or pharmacist that it is safe to take with your other medicines. Besides, make sure that you understand your proper dosing regimen.

If you are having an operation or any dental treatment, it is necessary to inform your doctor about using Amoxil.

In the event that you have some questions about proper use of the medicine or correct dose for your condition, ask your caring doctor. Learn all the necessary information and details of use before you start the treatment.

Microbiological parameters of Amoxil

Amoxicillin has the same bactericidal effect as ampicillin. It is bactericidal against bacterial organisms when they are actively dividing. The medicine stops the biosynthesis of cell walls and thus prevents the development of the disease.

In vitro and in vivo Amoxicillin has been proven to be active against the strains of the following microorganisms: Aerobic Gram-Positive Microorganisms • Enterococcus faecalis • Staphylococcus spp. • Streptococcus pneumoniae • Streptococcus spp. • Staphylococci susceptible to amoxicillin Aerobic Gram-Negative Microorganisms • Escherichia coli • Haemophilus influenzae • Neisseria gonorrhoeae • Proteus mirabilis Helicobacter pylori Various types of infectious diseases caused by bacteria are effectively treated with Amoxicillin.

What other medicines will affect clavulanate and Amoxicillin?

iCAVJADC9

Before taking clavulanate or Amoxicillin, tell your provider if you are using any of the following medicines:

  •   probenecid (Benemid); or
  •   allopurinol (Zyloprim);
  •   another antibiotic (for a different or for the same infection).

The patient may not be able to use clavulanate or Amoxicillin, if he is using any of these medicines, he may need  special tests or dosage adjustments during treatment.
This drug can make birth control pills less effective, because we recommend to use a  diaphragm/condom/spermicide).

Side effects of Amoxil


Evry patient must know that he may side effects and allergic reaction to Amoxil, because very important consult with health care provessional if you want to star take Amoxil.
Serious side effects:

  •  swollen glands,
  •  white patches or sores inside your mouth or on your lips;
  •  confusion or weakness
  •  fever, itching or rash and  general ill feeling;
  •  red skin rash
  •  peeling,
  •  severe blistering,and;
  •  joint pain,
  •  yellowed or pale skin fever, , dark colored urine,;
  •  yellowing of the eyes,
  •  severe tingling, numbness, pain, muscle weakness; or
  •  red/ purple pinpoint spots under your skin, easy bruising,
  •  unusual bleeding (rectum, nose, vagina, mouth ).

Less serious Amoxil side effects may include:

  •  nausea
  •  stomach pain,
  •  vaginal  discharge or  itching;
  •  headache; or
  •  vomiting;
  •  black/swollen/”hairy” tongue.